Emerging evidence on the location of stem cell niches present within the hypothalamus in adults.
01/12/2009 16:37
Emerging evidence has recently been discovered that the set of cells expressing FGF3 and SOX3 of the anterior floor plate flanking the developing infundibulum are important for the maintenance of a stem cell niche. This niche is believed to be acquired by the maintenance of SOX3 and FGF3 expression due to FGF10. These cells remain in a quiescent state in adults however according to emerging evidence both: stem cell and adjacent progenitor-like tanycytes thought to respond to the protein FGF2 and promote the proliferation of these cells. Further research is required however these stem cell niches are believed be located along the central/posterior hypothalamus adjacent to the third ventricle.